Z-Drugs
Last reviewed Friday, January 24, 2025“Z-Drugs” (e.g., zolpidem, zaleplon, eszopiclone) are non-benzodiazepine sedative-hypnotics typically prescribed for insomnia. They act on the GABA system but have a different chemical structure than benzodiazepines.
Key Points:
- Uses: Short-term management of sleep onset or sleep maintenance insomnia.
- Side Effects: Drowsiness, dizziness, possible dependence, “sleep behaviors” (e.g., sleepwalking, sleep-eating) in rare cases.
- Precautions: Avoid mixing with alcohol or other CNS depressants; recommended for brief durations.
